The Celtics' attempt to win the Eastern Conference Finals after falling behind 3-0 was severely hampered in just 26 seconds.
Star forward Jayson Tatum attempted to take on Miami's Gabe Vincent in the paint after receiving a pass from Al Horford.
Tatum rolled his ankle after he landed on Vincent's foot after attempting to Euro step around Vincent and attempted a disputed jumper.
Tatum tried to play through his apparent pain after the play, but he wasn't as effective as normal as the team lost to the Heat 103-84.
"I saw it after the game when I came down, my ankle and it's tough because it kinda impacted me the rest of the night, swelled up," Tatum said following the game.
"I was just kind of like a shell of myself, which was frustrating. Moving is difficult. Simply put, it was irritating, especially because it happened on the opening play.